[rat-forum] DISCOVERY STRATEGIES Conference: May 16-18, 2005

Judi Medlin judi.medlin at jax.org
Thu Mar 3 09:21:17 CST 2005


"Improving the Predictive Value of Mouse Models in Drug Discovery and Development"

Hosted by: The Jackson Laboratory Research Affiliates Program

Location: Bar Harbor, Maine, USA

Date: May 16-18, 2005

For more information with online registration now active, please visit 


ABSTRACTS for the poster session are being accepted via email to discovery at jax.org

Please limit your abstract to one 8 1/2 x 11" page with one inch margins. The presenter's name must be underlined in the author list. Abstracts should be submitted no later than April 1st. Notifications of acceptance will be sent the last week in April.

Conference Overview:

Bringing together some of the best minds from both academic and industrial sectors, this year's Discovery Strategies meeting examines how the promise of select technologies and resource initiatives may be applied to expediting the delivery of safe, effective drugs to the clinic.

Session I, Emerging Technologies and Strategies, focuses on how new approaches are being used to leverage the enormous power of the mouse in discovery, research and development. In particular, advances in key modeling areas will be addressed including new knockout strategies, humanization of the laboratory mouse and the application of siRNA in modeling potential new therapies.

Session II, Phenotyping, emphasizes new strategies and resources that are being developed to provide comprehensive phenotype data on diverse mouse strains used in biomedical research, and how these resources are being used in pharmaceutical development.

Session III, Mapping Functional Networks, examines the use of mouse models in pharmaceutical development from a systems biology perspective. New approaches to the identification of functional networks underlying complex disease will also be presented.

Session IV, Intellectual Property Rights, will convene a panel of experts to discuss intellectual property rights and how to promote sharing of intellectual resources across diverse sectors.

Session V, Predictive Modeling of Drug Efficacy and Safety,  explores issues in modeling human responses to drugs and how existing methods of predicting efficacy and safety might be improved.

Topics include:

*siRNA tumor therapy using nanoparticles

*Stem cell technologies


*Eumorphia Project

*Mouse Phenome Project

*Phenotyping of genetically modified organisms: a drug development perspective

*Onco therapeutics

*Mutagenesis and QTL mapping

*Mapping networks

*Gene Traps, targeting and the mouse knockout project

*Expression profiling metabolic disease

*Leveraging genetic variation across laboratory mouse strains to predict clinical toxicity

*Comparative approaches to predicting clinical safety using rats and mice

For more information with online registration now active, please visit 


Judi Medlin

Conference Specialist

Courses and Conferences

The Jackson Laboratory

600 Main Street

Bar Harbor, ME 04609

Phone:  207-288-6326

Fax: 207-288-6080

Please check out our web site http://www.jax.org/courses/events/current.do 

for the current listing of courses and conferences at The Jackson Laboratory.

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