[rat-forum] High-throughput phenotype data in MGI

David Shaw David.Shaw at jax.org
Tue Feb 5 13:52:47 CST 2013


MGI now integrates phenotype data from high-throughput phenotyping centers with curated data from scientific publications, providing comprehensive comparative phenotypes for mouse mutants. Current data sets include those from the Wellcome Trust Sanger Institute (WTSI) and the Europhenome (EuPh) data. This integration allows specific comparisons between different Center data interpretations and is a model for future MGI data integration from the International Mouse Phenotyping Consortium (IMPC). All data on the MGI website are refreshed weekly.

MGI now includes 45,956 genotypes with phenotype annotations and mouse models are described for 1207 human diseases. 

MGI Allele Summary Pages have been streamlined, concatinating biological systems where phenotypes have been detected while removing the details of each genotype examined. In addition, Allele Detail pages have been redesigned for clarity and performance, and to display results from these high-throughput phenotyping centers. Sex-specific phenotype data also are easier to discover. 

For an example, see this MGI Allele Detail page: 
http://www.informatics.jax.org/accession/MGI:4460276

In the Phenotypes section of an allele detail page, you can click on the triangle for an affected system to see more detailed phenotypes, such as "decreased leukocyte cell number" for immune system phenotypes. You can see even finer details for MGI curated alleles by clicking on the Genotype icon, such as hm1 (hm for homozygous). 

Please send questions and comments to MGI User Support, 
mgi-help at jax.org.


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